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haemosiderosis

Alternative Names
idiopathic pulmonary haemosiderosis, IPH, pulmonary haemorrhage

Definition
Haemosiderosis is a rare, often fatal, condition in which iron builds up in the lungs. The iron is in the form of haemosiderin, a pigment in blood. Haemosiderosis results from bleeding into the lungs, also known as pulmonary haemorrhage.

Pulmonary haemosiderosis is often broken down into four categories:
  • idiopathic, which means it occurs by itself
  • occurs along with pancreatic or heart disease
  • occurs along with a milk sensitivity
  • occurs along with a kidney disease called glomerulonephritis
What is going on in the body?
This condition usually shows up between the ages of 6 months and 20 years. Blood that leaks out of the capillaries is taken up by scavenger cells in the lung. The breakdown products of the blood irritate the lung and lead to scarring.

What are the signs and symptoms of the condition?
Symptoms include: What are the causes and risks of the condition?
Haemosiderosis is often linked with anaemia and chronic infections. It may also be caused by problems with the heart or the immune system.

Pulmonary haemosiderosis is more common in children under 10 years old. It is equally common in boys and girls. When it begins in adulthood, it is more likely to affect males.

What can be done to prevent the condition?
Prevention is based on treating the underlying cause. If another condition causes bleeding into the lungs, haemosiderosis can develop.

How is the condition diagnosed?
Diagnosis begins with a medical history and physical examination. Diagnostic tests may include: The diagnosis is often made by ruling out other causes of bleeding into the lungs.

What are the long-term effects of the condition?
If haemosiderosis is not effectively treated, long-term effects from the bleeding and kidney damage can include: What are the risks to others?
Haemosiderosis is not contagious. If the underlying cause is an infection, that infection may be contagious.

What are the treatments for the condition?
The treatment depends on the cause. Blood transfusions may be needed for blood loss. Supplemental oxygen is given for low levels of oxygen in the blood. Corticosteroids and medications that suppress the immune system are often used. If the cause is sensitivity to cow's milk, a milk-free diet may be recommended.

What are the side effects of the treatments?
Side effects depend on the treatment used. Side effects of steroids may include stomach upset, jittery feelings, muscle weakness, bloating, and weight gain.

What happens after treatment for the condition?
Pulmonary bleeding can recur from time to time and will need to be evaluated.

How is the condition monitored?
This condition is monitored for the rest of the person's life. Any further bleeding in the lungs must be evaluated. The doctor should be told about any new or worsening symptoms. Blood tests, pulmonary function tests, and chest x-rays may also help monitor the course of the disease.

Author: Eileen McLaughlin, RN, BSN
Reviewer: HealthAnswers Australia Medical Review Panel
Editor: Dr David Taylor, Chief Medical Officer HealthAnswers Australia
Last Updated: 1/10/2001
Contributors
Potential conflict of interest information for reviewers available on request


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